Since the opening of the Reina Sofia Foundation Alzheimer Centre (CAFRS) in 2007, numerous research projects have been carried out at CIEN, both with public and private funding that have come to an end. However, due to the magnitude and importance within our centre, we wanted to keep some of them in this section, since their cohort of volunteers continues to nurture subsequent projects and because the data and samples collected continue to be used to carry out other studies, such as the Vallecas Project, funded for 10 years by the Reina Sofia Foundation.